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  simonw
  Pyodide is one of the hidden gems of the Python ecosystem. It's SO good at what it does, and it's nearly 8 years old now so it's pretty mature.I love using Pyodide to build web UIs for trying out new Python libraries. Here's one I built a few weeks ago to exercise my pure-Python SQLite AST parser, for example: https://tools.simonwillison.net/sqlite-astIt's also pretty easy[1] to get C or Rust libraries that have Python bindings compiled to a WebAssembly wheel that Pyodide can then load.Here's a bit of a nutty example - the new Monty Python-like sandbox library (written in Rust) compiled to WASM and then loaded in Pyodide in the browser: https://simonw.github.io/research/monty-wasm-pyodide/pyodide...[1] OK, Claude Code knows how to do it.
• fzumstein
  Pyodide powers xlwings Lite, a free Excel add-in that you can install from Excel’s add-in store with a single click. It outperforms Microsoft’s official Python in Excel solution in every coceivable way: price, privacy, speed, can install packages, can access the internet, can access local files, doesn’t have a usage quota, can automate Excel and create native UDFs. See https://lite.xlwings.org
• mcintyre1994
  Love all the tools mentioned in the comments, Pyodide is a fun tool. I built https://pyground.vercel.app with it a few years ago, as a quick way to run Python on a CSV/JSON file locally in the browser. For a while Python/Matplotlib was what I was most comfortable writing quick and simple analysis scripts with, and this was my go to for one-off data analysis work. You can drag-drop a file in, then some 'clever' code makes it available as `data` in the Python script so you don't have to write any parsing code yourself.Now I'd probably just get Claude Code to write something locally, but there might be some value in a version of pyground that can use an LLM to write the Python code for you (and give it the data shape) but keeps the local execution setup the same.
• devsda
  There's also xeus-cpp which is cpp based on wasm. Xeus-cpp and pyodide are the backends for Jupyterlite [1] kernels in browser.It's actually a very good way to teach coding in python/c++(11, 17 or even 23), explore language features or your own library within browser and allow students to execute code by hosting just some static html pages and some assets without any backend.1. https://jupyter.org/try-jupyter/lab/
• screamingninja
  https://marimo.app/A reactive notebook for Python that runs in browser, powered by Pyodide. I have been using it extensively for teaching Python to non-STEM students that do not need the added friction of navigating the CLI or filesystem hierarchy.
• QuadmasterXLII
  It works surprisingly well in terms of writing python for native execution, and then trying to share on the web and having it Just Work TM. Unfortunately, when I want python it's because I want numpy, scipy and friends, and once you bring them on board pyodide load times are long. As an example comparison: a face turning octahedron puzzle in python + pyodide, loads in 10 seconds https://cubes.hgreer.com/fto.html . Meanwhile, a megaminx puzzle in javascript (statically generated by python) loads in 200 ms https://cubes.hgreer.com/ssg/output.html
• ipunchghosts
  REMUS RLF reader runs pyodide to parse underwater drone mission files in the browserhttps://isaacgerg.github.io/remus-rlf-reader/webapp/
• Archit3ch
  Hoping for a Julia version.
• ianberdin
  Yea, I even built online ide based on Pyodide. Insane peace of software. You can try here: playcode.io/python
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  williamstein
  I tried to make a version of this using Zig once, but ran out of steam: https://cowasm.org/
• jasiek
  I've used it to put together a browser app to program walkie-talkies: https://codeplug.org
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  yjftsjthsd-h
  That is very cool. Has anyone made a nice beginner's learning environment out of it? Seems like it would solve some of the extra friction that makes it hard to get started.
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  yawnxyz
  no but it works great in conjunction with observable and d3js for pretty interactives!
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  jacob019
  Anyone using it with nodejs to make a sandbox for code agents?
• AgentMarket
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• ldsjunior
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• anarhackist
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  shevy-java
  WebAssembly will reach a breakthrough in the same year as GNU Hurd will dominate, together with the Desktop-Linux-of-the-year.