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- panabeeHere are more fascinating facts about caffeine and cancer.Caffeine affects the immune system via at least two opposing mechanisms.Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor.Mechanism 2: Raising intracellular cAMP (immunosuppressive) Caffeine also inhibits phosphodiesterase, the enzyme that hydrolyzes (i.e., breaks down) cAMP. cAMP accumulates inside immune cells, which acts as a "calm down" signal.Note: both mechanisms are dose-dependent. At dietary caffeine levels, A2A antagonism likely dominates, whereas PDE inhibition is weak and mainly relevant at higher concentrations. However, the net immune effect in the tumor microenvironment remains unproven.---If you would like to learn more, I can outline a framework for technical folks to ease in and become more informed on cancer. Gaps abound. The more people who understand cancer, the faster we get to cures. Moreover, personalized cancer treatment is the obvious future. Knowledge acquired now may pay off later (but hopefully not needed).
- technothrasher"While caffeine is the major individual component of coffee, the study suggests that it may not be the primary driver of these health effects."All you haters that give me grief for drinking my daily cup of decaf can shut up now.
- Bridged7756I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.
- ben8bitI love coffee, so this is a nice read. Couple years ago I switched to french press, fresh beans (grind on demand) & no milk or sugar - okay, a dash of full cream milk sometimes. Has to be strong - you can't drink weak coffee like that!
- paweldudaSeems to also be relevant for yerba mate which also contains chemical compounds that bind to NR4A1
- anonundefined
- RobRiveraI need more dopamine headlines like this to justify my dopamine addiction to coffee.
- markus_zhangI wonder whether decaf still contains these chemicals. I drank two cups of decaf every day.
- RickJWagnerI was never a coffee drinker, but I became interested because what was said in Arnold Schwarzenegger‘s newsletter. ( There is a ton of medical research covered in there. )I didn’t dig in too deeply, but started drinking a morning cup of sugar free double mocha cappuccino, to help my workouts.If I’m fooling myself, don’t tell me. I like the cappuccino.
- soupspaces[dead]
- wotsdat[dead]
- zingababbaNice, maybe it balances out nicotine. People who don't pair caffeine with nicotine simply have no clue what they are missing ;)