HN

Comments (106)

• Menu

  gcanyon
  As is often the case, the title is hyperbolic. The discovery applies to 20% of tumors, and "one of cancer's significant defenses" or "a key weakness of cancer" would be more accurate.That said, I'll happily take "we discovered a key weakness in 20% of cancers," please and thank you.
• Menu

  gavinray
  To offer context for others:The bigger deal about this is that KRAS was considered an "undruggable" target.Recent advancements have allowed us to design biologics to do things we previously thought impossible, which broadens the horizons for other treatments in the future.Baby steps.
• Menu

  ispeters
  https://archive.ph/d4mT2
• variety8675
  The study this article references is here: https://clinicaltrials.gov/study/NCT06625320
• Menu

  pdar4123
  Please remember that science is under attack in the United States - new proposals would gut the nih even beyond the horror that is ongoing. As a scientist I am horrified and I truly hope that we don’t abandon the usas historically strong investment in the future.
• Menu

  v3ss0n
  How many cure for cancer news we have 10 yrs ago and none of them goes online?
• btown
  Another ongoing HN thread from yesterday around some exciting cancer treatment breakthroughs, this time with a CRISPR Cas12a2 mechanism: https://news.ycombinator.com/item?id=48505231This subthread there is a fascinating explainer about one user's journey into funding and incentivizing research into their own rare form of blood cancer, and how they are able to push forward the state of the art: https://news.ycombinator.com/item?id=48506997 - something of a modern-day (and more accurate) Lorenzo's Oil!
• Menu

  an0malous
  I’m surprised Michael Levin’s research hasn’t expanded much beyond a certain YouTube media bubble. They’re able to start and stop cancer growth with only voltage changes between cells, likewise they can also trigger regeneration or anatomical changes using voltage changes. His research seems to suggest a lot of important anatomical plans are stored in an electric field around the body, not in the DNA. This model’s explanation for cancer is that some cells become disconnected from this field and start growing independently of the overall body plan.
• Menu

  pancreaticdiet
  If anyone finds this thread because they or someone in their life is currently facing down a pancreatic cancer diagnosis I want you to know that we had significant success with our loved one by focusing, on our end, on diet.The patient's metastasis markers were so high the value was literally off of the maximum value on the graph on the chart they gave us in the literature, and so, well beyond the level of being surgery eligible.Over the 12 chemo cycles that number dropped to levels that cancer free people have, and they have gone on to outlive almost every statistic and remain cancer free to this day.When researching pancreatic cancer following their diagnosis one thing that stood out to me is how the majority of scientific knowledge surrounding cancer addresses the cancer's metabolism. Pancreatic cancer is an IGF-1 (Insulin Growth Factor) metabolic cancer. This can be interpreted as the cancer uses sugar as its fuel source to grow, and in the absence of sugar can alter its internal metabolism to use an amino acid called glutamine as fuel instead. Glutamine is an amino acid found in animal products such as meat and dairy.With this knowledge we went with a food regiment of removing ALL sugar, and animal products.The results were significant. Even in their 70s they were able to do the full 12 cycle chemo treatment without needing to delay a single cycle due to negative health markers, and without any major side effects (except fatigue).The tumor shrunk form 4.2 cm to 2 cm after 6 chemo treatments, and finally shrunk to 1 cm following their final treatment before surgery. (Compare this to studies on tumor shrinkage for the same cancer and chemo treatment, such as: https://www.healio.com/news/gastroenterology/20210722/early-... )It is my opinion that at this time medical treatment is essential, both chemo and surgical intervention, but if you want something that you can do to try to increase the efficacy of those treatments I highly recommend this nutritional vector as well!Best wishes for you and your loved ones.
• sharts
  May have? It also may have not.
• Menu

  onesandofgrain
  We should be spending the same amount of money on health and disease as we spend on AI. Ogogogogogo
• anon
  undefined
• siimianwords
  [dead]
• DivingForGold
  Thanks for posting useful link !