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Comments (288)

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  dirtbagskier
  I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary.The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.
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  joshuamcginnis
  Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.
• storus
  Metabolic theories of mental illnesses and cancer are seriously understudied.
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  hellzbellz123
  As a habitual habit developer, Im keeping my hopes up that in 5 or 10 years, this is something that can help me and many others.I've read experiences from people on illicit substances that claimed they helped them quit.It would be beat if this carried over to things like caffeine/nicotine/thc/etc.
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  zhivota
  Tirzepatide at 1mg/week reduced my muscle soreness. I felt less depressed but this might just have been situational because I've been plagued by bad soreness after working out for years.Unfortunately after twelve weeks I had to stop because I felt a lot of nausea and tenderness in my upper abdomen, and was worried it might be pancreatitis developing. I'm not sure why it would happen at such a low dose but the symptoms reduced pretty quickly as it wore off.I may go back on later with a dose spread over a longer period with the hypothesis that the drug has a longer half life in my body and what I experienced was a gradual build up. Considering I lost 15 pounds over 3 months as well, I believe this to be very plausible.
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  y-curious
  I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.
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  OptionOfT
  My insurance stopped covering, now I'm looking at $450 for Zepbound / month. Just the weight coming back is making me more depressed...
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  crooked-v
  I'm curious if this post will also have the same phenomena I've seen before of people springing out of the woodwork to post moralizing comments about people shouldn't rely on drugs, about how actually GLP-1s are bad because they don't fix problems indefinitely with a single dose, about how people should fix their problems by just having more willpower, talking about 'but what about the unknown side effects?' of drugs that have been in use for twenty years already, etc.
• anon
  undefined
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  devcatapult
  What about the reports of bone density loss? Any downsides to this?
• TMWNN
  The more I hear about GLP-1 drugs, the more I think there is something to the joking suggestion of putting it in the water supply.
• jbird99
  Could be related to endorphins and BDNF, similar to the effect from fasting.
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  replwoacause
  Hasn't done jack shit for my depression.Also worth mentioning GLP1's are known to cause anhedonia. So there's that...
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  dyauspitr
  What’s the downside to this magical drug. There has to be a downside…
• jona-f
  The "gut-brain axis" is mostly bullshit invented to cope with the fact that doctors have sent patients to shrinks for decades with real sicknesses. Everybody knows you feel bad when your digestive is out of balance. It's the same english word for "I'm sick" and "I feel sick" since forever. No magical newly found "gut-brain axis" needed.Eating junk food, especially sweetened food is a drug. You can do a withdrawal and get the reduction of food noise reported with semaglutide without getting dependent on another drug with so far unknown long-term effects.
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  vladmk
  Mice are not people, but interesting link
• metalman
  so, the whole mouse thing is a scam, and now they are openly testing on us, first, and publishing in psychology today to see if we notice.fiendish.