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Claude discovers a novel enzyme system with CRISPR-like repeats

Claude discovers a novel enzyme system with CRISPR-like repeats

raahelb

Comments (332)

  • shonenknifefan1
    > While combing through the raw DNA sequence near the RT, the agent exclaimed: “[The DNA next to the RT] is spectacular: I can see by eye a tandem repeat array … that's a CRISPR-like … repeat array?!”I love that with AI discoveries, we can relive the discoveries from agent transcripts like this.I'm sort of imagining future histories involving notable AI events peppered with direct quotes like these.
  • jokoon
    I don't understand how an LLM is able to reason about those thingsLLM use language, but it can't "think" about biochemistryI saw that LLM have reasoning capabilities, which is different from machine learning, but I don't understand how it works.
  • evolarjun
    It is odd (or maybe not) that they decided to publish a marketing whitepaper rather than a more traditional journal submission + preprint. The work does appear to be sufficient for a publication, though there's a good chance a reviewer will rip into them for some of the assertions they make, but given the topic I'm sure the paper will be accepted regardless.The market for entry-level programmers has already declined, but at least they were somewhat in demand and made reasonable salaries. Now what happens to post-docs who already make almost nothing and often get treated like crap?
  • aakil
    This shows why biology is so much harder a problem area for LLMs than math, finding RTs is tedious but pretty doable today, they had to scope the problem down a lot from something that would be the equivalent of Navier Stokes in biology. Glad they’re doing it though, even if it’s just marketing.
  • ryanschaefer
    I’m confused why AI companies are using agents in-house for this type of research instead of partnering externally.I guess the improvement loop is tighter and they have more control over how discoveries can be used for marketing?But, in my mind, it begins to feel like they are setting themselves up to be “everything” companies instead of focusing on their core product…
  • actinium226
    Did Claude find this on it's own, or did somebody using Claude find it?
  • AbstractH24
    I recently heard Anthropic quietly setup its own bio lab.That it’s plausible that they’ll move from selling tokens as their primary source of revenue to building frontier models to do cutting edge research, and using the research as their primary source of revenue rather than release the models. Because it’ll be far less of a race to the bottom than commodified tokens used by the general public.Will be interesting to see how this all unfolds. (No pun intended, but there is a funny one there…)
  • gaigalas
    Pacing that frontier with some bioengineering gain of function
  • modeless
    It's clear Dario believes that the solution to AI's PR problem is to cure cancer. Or invent other revolutionary medical treatments. They're going to heavily promote every step along the way no matter how small or far away from commercialization they are, like this one.No doubt that curing cancer would help, but I think the timeline might be a little too long. Even RSI AGI will not be able to get new medical treatments to market instantly. Real world testing takes a long time and is an unavoidable part of the process.
  • bonsai_spool
    Very cool! However, the amazing absence of results makes me question whether they've got a Nature letter forthcoming or whether they know that another AI lab has a similar finding...
  • porridgeraisin
  • contemporary343
    I'm sorry but this would be a mediocre paper at best. And if this were a student presenting this for a qualifying exam, you can bet a committee would be ripping them a new one for presenting this with no understanding of what it does.
  • Sol-
    "Investigating the novel enzyme incident in our SF lab [2027]"
  • hmokiguess
    I'm getting tired of the marketing.There are so many people involved on this yet we still say things like "Claude did", we need to start waking up and being more real about how we are still in "AI + Human" land.What's wrong with saying "A team of researchers backed by Anthropic using Claude discovers a novel enzyme system with CRISPR-like repeats" or, ffs, mention the lead researcher in the headline?
  • ex1fm3ta
    LLMs are really good at discovering patterns on huge dataset. Google also had similair breakthrough discoveries they stopped marketing them
  • 6thbit
    when they say "claude" what model do they mean ?no mention of opus/mythos/fable or anything..
  • MachineMan
    Don't use it for biology, Dario said, as he turned humans into Teenage Mutant Ninja Turtles.. I reckon that soon, he too will return to dimension X.
  • cactusplant7374
    Was he paid to review the paper? His praise reads very unauthentic.> After reviewing the pre-print, Feng Zhang, one of the pioneers of CRISPR genome editing and a professor at MIT and the Broad Institute said:> This is an exciting example of how AI agents can contribute to biological discovery. The identification of RNA-repeat arrays associated with reverse transcriptases is genuinely intriguing and merits further investigation. I hope this work encourages more scientists to explore how AI can support their research.
  • mullingitover
    This is great, but I can't help but wonder if we're going to have another post next week with a lab complaining that they were about to publish this same finding, and they had Claude proofread their paper, and whoops how'd that get into Anthropic's training data?
  • Chance-Device
    I think this approach of actually doing useful science is better PR than hiring an army of influencers to shill for you, OpenAI style.Generally speaking, hiring an army of influencers to shill for you results in bad PR, and comments like this one.
  • lossolo
    > Anthropic sets up Bay Area lab beyond computer simulation work, two sources say> Startup aims for Claude AI to direct robots in lab environments, one source says> Company to stop short of clinical trials to avoid drugmaker competition, life sciences head sayshttps://www.reuters.com/world/anthropic-quietly-sets-up-biol...
  • doctorpangloss
    Aren't there unlimited mechanisms like this? Isn't this why Doudna isn't a billionaire (you can patent something, but it's easy to create another one and patent it separately)?
  • nonameiguess
    I wish we could discuss this in a way that didn't immediately devolve into people shouting up or shouting down that this is either meaningless or singularity.Caveating I'm not a biologist, but my understanding of the way this kind of thing works right now is a basic three-step process:1) Find molecules and DNA/RNA sequences in the wild and catalog them.2) Discover interesting subsequences among these.3) Figure out whether any useful applications can come from what was discovered.All three of these generally take a long time. Systematic automatic analysis of known databases speeds up and removes some of the luck from 2. But 1 and 3 are still long poles. 1 has the further issue that we usually discover these in existing organisms. I recall much of the outcry over tropical deforestation back in the 90s and replacing of rainforests with palm oil monoculture today is that the vast majority of terrestrial biodiversity is found in rainforests, and destroying them at industrial scale risks losing potentially useful molecules forever. 3 has the problem that you need to conduct physical experiments, and are limited by the speed of biochemical reactions no matter what and by the speed at which human subjects can be found and ethically experimented on assuming we care about being ethical.A lot of good can come of this, but I don't see a path to singularity here, assuming we're talking the original Kurzweil meaning there of all technological progress that will ever happen all happening at once. Data collection and experimentation on living subjects, human or not, can only happen so fast, regardless of automation. It's not computational. Whenever you have to interface with the real world, you're now working at the speed of the real world, not the speed of electricity. CRISPR was discovered in 1987 and first used to edit a gene sequence in a human zygote in 2015. I'm sure there are plenty of ways to make the candidate discovery to human application step not take three decades, but it's never going to be three months, either.
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  • catigula
    This work seems directly dangerous to me?
  • eqmvii
    In a year or two, articles like this will either be artifacts from peak hype or evidence of the beginning of the singularity. Right?
  • hn_submit
    Fake news to pump up their share price. You can't trust any news about A.I. these days, especially near their IPOs.This A.I. hype makes the Internet Bubble look like a walk in the park.
  • anon
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