HN

Comments (24)

• flopsamjetsam
  The two papers:* https://www.nature.com/articles/s41586-026-10955-0* https://www.cell.com/cell/abstract/S0092-8674(25)00853-0
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  dyauspitr
  So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.Do we currently have the ability to do targeted methylation or de methylation at sites in cells?
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  Chance-Device
  I suspect that epigenetic aging is adaptive; a deliberately programmed sequence wherein genes more likely to contribute to age-related mortality are shut down progressively. This being in response to random genetic damage accumulating at a predictable rate.What we think of as aging then becomes primarily the epigenetic response to the problem of DNA damage, much like the symptoms of a virus are mostly the result of the immune response rather than the virus’s direct effects.